There are a couple good cancer fund raising groups out there. Pedal the cause is an annual ride in St. Louis and San Diego. 100% of the funds the riders raise goes to research. They have a small group of full time staffers, and the riders' entry fees pay salaries (none in the 6 figures) the rest is done by volunteers.
If it wasn't for their research, a very good friend's young daughter would not be alive today. The form of Leukemia she was diagnosed with had an 80% mortality rate within 1 year of diagnosis as recently as about 5 years ago.
There are some very good organizations out there that stretch their donations a very long way. You just have to do your homework.
PS: Some states require lottery winners to be made public by law. If it were me, I'd be making my plans, doing the press conference, and going into hiding for a while.