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You are correct that you want it sealed up. Ozone is heavier than air and will stack up in the vehicle as it fills the interior. The fresh air part is from the source. What I like to do is set the machine just outside the vehicle with a flexible dryer hose connecting the front of the machine to the window via a cardboard vent that allows for the ozone to pump into the vehicle and the machine to breathe fresh air doing so.
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It's going to take 2-3 cycles of 1hr each to completely disinfect and clear any odors for good. Run it for an hour, vent it for a bit, then run it again, air it out, etc. I also tend to do at least one cycle with the HVAC going in high on hot and another on high / cold.
Hmm. I don't really have a way of connecting a hose like that to mine. I guess I'll just have to make do. I really think the one I bought was busted though. It literally didn't do a thing. I couldn't even smell where it had ran. I've returned it and am trying another one.